{"id":19097,"date":"2026-06-12T16:29:09","date_gmt":"2026-06-12T09:29:09","guid":{"rendered":"https:\/\/www.tibdglobal.com\/product\/%e0%b8%9a%e0%b8%a3%e0%b8%b4%e0%b8%81%e0%b8%b2%e0%b8%a3%e0%b8%97%e0%b8%94%e0%b8%aa%e0%b8%ad%e0%b8%9a%e0%b8%84%e0%b8%a7%e0%b8%b2%e0%b8%a1%e0%b8%84%e0%b8%87%e0%b8%95%e0%b8%b1%e0%b8%a7-7\/"},"modified":"2026-10-01T16:03:28","modified_gmt":"2026-10-01T09:03:28","slug":"extract-stability-testing","status":"publish","type":"product","link":"https:\/\/www.tibdglobal.com\/en\/product\/extract-stability-testing\/","title":{"rendered":"Extract Stability Testing Service (Extract Stability Hub): Covering 7 Extract Formats and Encapsulation Systems"},"content":{"rendered":"
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Extracts are key raw materials in Thailand’s health and beauty industry, used as Active Ingredients in cosmetics, concentrated supplements, and traditional Thai herbal products. Long-term stability of extracts is a critical condition for finished product development and regulatory registration.<\/p>\r\n

The challenge with extracts lies in the diversity of formats and the different storage requirements across each one, from solvent-based extracts such as ethanol or oil solutions, water-based liquid extracts, spray-dried powder extracts, to Encapsulation Systems that enclose extracts within microscale capsules. Each format has distinct challenges and requires specific testing protocols.<\/p>\r\n

TIBD’s service covers stability testing for all extract formats per ICH Q1A(R2) and ICH Q7 (Active Pharmaceutical Ingredient) under ASEAN Zone IVb conditions. It encompasses Marker Compound analysis by High-Performance Liquid Chromatography (HPLC), Retest Date determination, oxidative degradation evaluation, and Encapsulation structure verification, conducted in partnership with VISBIO as an Independent Quality Assurance Verifier (IQAV).<\/p>\r\n[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column]\n\t\t

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<\/span>Extracts in Thailand’s Health and Beauty Industry<\/span><\/h4>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t<\/div>\n\t\t\n\t\t[vc_column_text css=”” woodmart_inline=”no” text_larger=”no”]\r\n

Extracts in the Thai industry fall into two main groups by origin. The first is Plant Extracts (Botanical Extracts), widely used in Thai herbal products, cosmetics, and supplements, including Turmeric extract, Andrographis extract, Centella extract, Moringa leaf extract, and Amla extract. The second is extracts from other sources such as probiotic bacteria, algae, and fungi.<\/p>\r\n

Commercially, extracts are typically produced and traded as Standardized Extracts with clearly defined Marker Compound content, for example Turmeric extract standardized to 95% Curcuminoids, Andrographis extract standardized to 10% Andrographolide, and Centella extract standardized to 80% Total Triterpenes. Standardization enables finished product manufacturers to formulate accurately and predict efficacy.<\/p>\r\n

Extract stability is a key factor in setting Retest Dates and in planning raw material procurement and storage. Extracts that degrade quickly must be ordered in small, frequent quantities, increasing management costs, while stable extracts can be purchased in bulk at lower unit cost.<\/p>\r\n[\/vc_column_text][vc_single_image image=”18838″ img_size=”full” alignment=”center” css=”” parallax_scroll=”no” woodmart_inline=”no”][\/vc_column][\/vc_row][vc_row][vc_column]\n\t\t

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<\/span>7 Extract Formats Supported by TIBD<\/span><\/h4>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t<\/div>\n\t\t\n\t\t[vc_column_text css=”” woodmart_inline=”no” text_larger=”no”]\r\n

TIBD provides stability testing for extracts across 7 primary formats and Encapsulation Systems, each with a purpose-built protocol.<\/p>\r\n\r\n

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  1. Solvent-Based Extract (Ethanol Extract)<\/strong> using ethanol, methanol, or other organic solvents for extraction and storage. Challenges include solvent evaporation and storage safety requirements.<\/li>\r\n \t
  2. Oil-Based Extract<\/strong> using vegetable oils such as coconut oil, sesame oil, or olive oil as the carrier medium. Challenges include oxidative degradation, Peroxide Value increase, and odor changes.<\/li>\r\n \t
  3. Water-Based Extract (Aqueous Extract)<\/strong> using water as the solvent. Challenges include microbial growth and long-term active compound degradation, requiring refrigerated storage.<\/li>\r\n \t
  4. Spray-Dried Extract (Powder Dry Extract)<\/strong> converted into stable long-term powder form through spray drying. Challenges include moisture absorption and powder caking.<\/li>\r\n \t
  5. Emulsion Extract<\/strong> dispersed in an oil-water system to enhance Bioavailability. Challenges include emulsion system stability over time.<\/li>\r\n \t
  6. Encapsulation Systems Extract<\/strong> using Microcapsules, Nanocapsules, or Liposomes to protect the extract and control release.<\/li>\r\n \t
  7. Herbal Extract<\/strong> governed by the Herbal Product Act B.E. 2562 (2019), covering single herb extracts and multi-herb formulation extracts.<\/li>\r\n<\/ol>\r\n

    Each format has a dedicated article covering its specific parameters, acceptance criteria, and format-specific considerations.<\/p>\r\n[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column]\n\t\t

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    <\/span>The Retest Date Concept for Extracts and Active Ingredients<\/span><\/h4>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t<\/div>\n\t\t\n\t\t[vc_column_text css=”” woodmart_inline=”no” text_larger=”no”]\r\n

    Extracts and Active Ingredients use a Retest Date rather than an Expiry Date as applied to finished products. A Retest Date is the date by which the extract must be re-tested to confirm it remains within specification, not a disposal date.<\/p>\r\n

    The principle of Retest Date per ICH Q7 is that an extract stored under defined conditions may continue to be used as long as it passes testing at the Retest Date and still meets its specifications. This approach reduces raw material waste and helps manufacturers plan procurement efficiently.<\/p>\r\n

    Retest Date determination is based on stability data tested under defined storage conditions. Extracts stored under refrigeration (2-8\u00b0C) typically achieve a longer Retest Date than those stored at room temperature.<\/p>\r\n[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column]\n\t\t

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    <\/span>Testing Parameters Specific to Each Format<\/span><\/h4>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t<\/div>\n\t\t\n\t\t[vc_column_text css=”” woodmart_inline=”no” text_larger=”no”]\r\n

    TIBD’s protocols cover parameters specifically designed for each extract format.<\/p>\r\n\r\n