{"id":19141,"date":"2026-06-17T16:15:08","date_gmt":"2026-06-17T09:15:08","guid":{"rendered":"https:\/\/www.tibdglobal.com\/product\/herbal-tablet-stability\/"},"modified":"2026-10-06T13:27:21","modified_gmt":"2026-10-06T06:27:21","slug":"herbal-tablet-stability","status":"publish","type":"product","link":"https:\/\/www.tibdglobal.com\/en\/product\/herbal-tablet-stability\/","title":{"rendered":"Lycap and Film-Coated Herbal Tablet Stability Testing Service"},"content":{"rendered":"
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Lycap (\u0e25\u0e39\u0e01\u0e01\u0e25\u0e2d\u0e19) is a traditional Thai herbal dosage form prepared by mixing finely ground dried herbs with a binder such as honey or syrup and shaping the mixture into small spheres. This format has been used in Thai traditional medicine for centuries and remains widely produced under the Thai National Formulary and the Herbal Product Act B.E. 2562 (2019). Film-Coated Herbal Tablets apply a thin polymer coating over a compressed tablet core to protect the active herbal ingredient, mask bitter taste, and improve product presentation. Both formats present specific stability challenges in the hot and humid ASEAN Zone IVb environment, including Coating Film instability, moisture absorption affecting Disintegration, Marker Compound degradation, microbial growth in honey-bound Lycap with high Water Activity, and color change from natural pigment degradation.<\/p>\r\n

TIBD’s service is designed specifically for Lycap and Film-Coated Herbal Tablets, covering Hardness, Disintegration Time, Friability, Weight Variation, Content Uniformity, Moisture Content, Water Activity, Coating Integrity, Coating Thickness, Dissolution, Color assessment by CIE La<\/em>b* Colorimeter, and Marker Compound Assay by High Performance Liquid Chromatography (HPLC) under ASEAN Zone IVb conditions per ICH Q1A(R2), in partnership with VISBIO as an Independent Quality Assurance Verifier (IQAV) using Validated Methods per ICH Q2(R1).<\/p>\r\n[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column]\n\t\t

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<\/span>Herbal Tablet Product Types in the Thai and ASEAN Market<\/span><\/h4>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t<\/div>\n\t\t\n\t\t[vc_column_text css=”” woodmart_inline=”no” text_larger=”no”]\r\n

Six herbal tablet and Lycap product types are commercially produced in Thailand and the ASEAN region.<\/p>\r\n\r\n

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  • Traditional Lycap prepared per the Thai National Formulary includes classical formulas such as Sek Sam Sip (\u0e2a\u0e31\u0e01\u0e01\u0e30\u0e17\u0e34\u0e49\u0e07 \u0e2a\u0e32\u0e21\u0e2a\u0e34\u0e1a), Ya Hom (\u0e22\u0e32\u0e2b\u0e2d\u0e21), Triphala (\u0e15\u0e23\u0e35\u0e1c\u0e25\u0e32), and Phaya Yo (\u0e1e\u0e0d\u0e32\u0e22\u0e2d). These products must match the declared formula composition per the National Formulary specification and meet the identity, purity, and Marker Compound requirements of Thai Herbal Pharmacopoeia 2021 (THP 2021).<\/li>\r\n \t
  • Contemporary Lycap is produced with concentrated herbal extracts and defined Marker Compound content, targeting the nutraceutical market. These products combine traditional format with modern quality control, allowing quantitative Marker Compound claims on product labeling.<\/li>\r\n \t
  • Film-Coated Tablets use a water-soluble polymer film coating applied by spray coating, with HPMC (Hydroxypropyl Methylcellulose), PVA (Polyvinyl Alcohol), and PVP (Polyvinylpyrrolidone) as the most common film-forming agents. Film coating reduces moisture ingress, improves appearance, and masks the characteristic bitter taste of many herbal extracts.<\/li>\r\n \t
  • Sugar-Coated Tablets apply successive layers of sucrose-based coating over the tablet core, producing a smooth, glossy appearance. This format has largely been replaced by film coating in modern production but remains in use for certain traditional products and pediatric formulations.<\/li>\r\n \t
  • Enteric-Coated Tablets use an acid-resistant polymer coating (HPMCP, Eudragit L100, or Methacrylic Acid Copolymer) to prevent dissolution in gastric acid and ensure release in the intestine. This format is used for herbal actives that are degraded by gastric acid or that cause gastric irritation.<\/li>\r\n \t
  • Sustained-Release Tablets are designed to release the active herbal ingredient gradually over an extended period. This format improves consumer compliance and maintains consistent plasma levels of the active compound.<\/li>\r\n<\/ul>\r\n[\/vc_column_text][vc_single_image image=”18979″ img_size=”full” alignment=”center” css=”” parallax_scroll=”no” woodmart_inline=”no”][\/vc_column][\/vc_row][vc_row][vc_column]\n\t\t
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    <\/span>Specific Stability Challenges of Lycap and Herbal Tablets in Tropical Climates<\/span><\/h4>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t<\/div>\n\t\t\n\t\t[vc_column_text css=”” woodmart_inline=”no” text_larger=”no”]\r\n

    Seven stability challenges specific to Lycap and Film-Coated Tablets must be addressed in a stability protocol designed for ASEAN Zone IVb conditions.<\/p>\r\n\r\n

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    1. The first challenge is Coating Film cracking, peeling, or stickiness under high temperature and humidity. Coating Film instability at 40\u00b0C \/ 75% RH causes visible appearance defects and exposes the tablet core to moisture, accelerating Marker Compound degradation and Disintegration Time changes.<\/li>\r\n \t
    2. The second challenge is moisture absorption affecting Hardness, Disintegration, and Dissolution. A change of more than 30% from the initial Disintegration Time is considered significant per ICH Q1A(R2) stability criteria and triggers a formulation review.<\/li>\r\n \t
    3. The third challenge is Marker Compound degradation. Curcuminoids, Andrographolide, and Asiaticoside are all sensitive to heat, moisture, and light exposure. Stability Indicating HPLC methods are required to distinguish the parent compound from its degradation products throughout the study.<\/li>\r\n \t
    4. The fourth challenge is microbial growth in honey-bound Lycap products. Lycap prepared with honey or syrup binders have higher Water Activity than compressed tablets, creating conditions favorable for yeast and mold growth under tropical storage conditions. Water Activity monitoring and microbial limit testing are required throughout the shelf life.<\/li>\r\n \t
    5. The fifth challenge is color change from Maillard reaction between reducing sugars and amino acids in the honey binder, or from degradation of natural colorants used in Sugar-Coated formulations. Color change is assessed quantitatively by CIE La<\/em>b* Colorimetry.<\/li>\r\n \t
    6. The sixth challenge is taste change affecting consumer compliance. While taste is assessed organoleptically, it is generally correlated with Marker Compound content data from the HPLC assay.<\/li>\r\n \t
    7. The seventh challenge is degradation of the Sustained-Release matrix for modified-release formulations, causing Release Profile changes and potential dose dumping. Dissolution testing at multiple time points is required for this format throughout the stability study.<\/li>\r\n<\/ol>\r\n[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column]\n\t\t
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      <\/span>Testing Parameters: Hardness, Disintegration, Friability, Coating Integrity<\/span><\/h4>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t<\/div>\n\t\t\n\t\t[vc_column_text css=”” woodmart_inline=”no” text_larger=”no”]\r\n

      TIBD’s stability testing protocol for Lycap and Herbal Tablets covers the full set of physical and chemical parameters required to characterize dosage form integrity and active ingredient content.<\/p>\r\n\r\n